Endocrine Abstracts

Multiple Endocrine Neoplasia Type 1(MEN1) syndrome is commonly associated with the three ’P’s-pituitary, parathyroid and pancreatic lesions. However, increasingly, thoracic neuroendocrine tumours (NETs) are being recognised with the syndrome. We present a case of MEN1 syndrome who primarily presented with a lung carcinoid tumour. A 31-year-old lady with without a significant past medical history presented with 2-month history of a persistent cough. ...

We present a rare case of a 50 years old lady who presented with new onset hirsutism and hoarseness of voice since 2 years. Investigations showed high serum testosterone, androstendione and free androgen index. All other systemic and endocrinology evaluation for hirsutism did not reveal any abnormality. CT scan of her abdomen showed a right ovarian mass which was confirmed as a Sertoli-Leydig cell tumour (stage Ia) on surgical staging and completely cured after bilateral salpi...

A 53 year old man, without any previous medical history, presented acutely to the Accident and Emergency Department with a 5 day history of vomiting and abdominal pain on a background of weight loss, fatigue, polyuria and polydipsia for 4 weeks. On examination he was obviously tanned and thin. He was clinically dehydrated and had palpable hepatomegaly. Immediate biochemical testing revealed hyperglycaemia with a venous blood glucose of 20.7 mmol/l, a metabolic acidosis with a ...

A usually fit 41-Year-old female was incidentally found to have a 9 cm left-sided adrenal mass during radiological investigations prior to an appendicectomy for acute appendicitis. She did not demonstrate any clinical features of adrenal hormone hyper- or hypofunction.Investigation: Further investigations were carried out to determine the nature of the mass and biochemically assess adrenal function. These revaled normal metanephrines: plasma metanephrine...

A 73-year-old man with a known history of Type 2 Diabetes, atrial fibrillation and hypertension presented with chest pain to the emergency department. His medication included metformin, bisoprolol, apixaban and omeprazole (long-term use). On clinical assessment, he complained of generalised aches and examination revealed bony tenderness over the chest wall. His electrocardiogram showed a prolonged QTc interval (495 ms). Biochemical tests revealed normal serum troponins, renal ...

A 57-year-old female who was previously healthy was admitted to hospital with a 2-week history of abdominal pain. On admission, she was tachycardic, tachypnoeic, hypotensive, and had abdominal tenderness. Her initial investigations revealed a neutrophilia with her biochemistry showing hyponatraemia (sodium of 124 mmol/l (135–145)) and normokalaemia (potassium of 4.7 mmol/l (3.5–5.5)). She had an urgent abdominal CT scan which showed evidence of a tubo-ovarian abscess...

Introduction: Ectopic ACTH syndrome (EAS) is associated with small cell carcinoma of the lung. It is reported as a rare condition. Here we report three cases of undiagnosed bronchogenic carcinoma who presented with EAS within a period of 12 months.Case 167-year-old lady, smoker, presented with severe proximal myopathy of 4 week duration. Clinically she appeared cushingoid. Newly diagnosed Type two diabetes. Lab tests – potassi...

Case history: We report the case of a previously healthy 69-year-old female who was referred to our centre after she presented with rapidly progressive weight-gain, hyperglycaemia, hypokalaemia and hypertension. She had no symptoms suggestive of carcinoid syndrome. On assessment, she had pathognomonic features of Cushing’s syndrome: central weight gain (peripheral wasting) proximal myopathy, leg oedema, skin thinning, bruising and facial puffiness; this appearance being m...

Background: Thyroid eye disease (TED) is common among patients with Graves’ disease (GD), with an estimated prevalence of 25-58%. While radioactive iodine (RAI) therapy is effective in managing GD, there are concerns regarding the risk of TED after RAI. Therefore, studying the effects of RAI on TED is essential for improving clinical decision-making. Aim: To determine the incidence of the development or exacerbation...

The usual management at our centre for patients awaiting phaeochromocytoma surgery involves pre-operative titration of alpha blockade with frequent clinic visits for blood pressure (BP) and heart rate (HR) monitoring. The COVID-19 pandemic restricted our ability to consult with patients frequently. To reduce infection risk, we incorporated virtual BP monitoring using a Microsoft Excel template coupled with regular remote consultations. We present a clinical case highlighting o...